Abstract
Atopic dermatitis (AD) is the first stage of the atopic march, which describes the phenomenon of increased rates of allergic rhinitis and allergic asthma observed in individuals with early AD. The skin barrier disruptions of AD are thought to provide a nidus for allergic sensitization to food and aeroallergens, which can then lead to increased allergic disease. Filaggrin is a key component of the epidermal differentiation complex of the stratum corneum in human skin. Loss-of-function mutations in the filaggrin gene have commonly been described in patients with AD and are associated with an increased risk of atopic sensitization in these individuals leading to asthma and allergic rhinitis.
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