Filaggrin Gene, Chromosome band 9q34.3, SPINK5, ALCAM and Transepidermal Water Loss

Abstract

Background Epidermal integrity and transepidermal water loss (TEWL) are highly correlated and crucial to healthy skin. Aim Review recent on the genetic control of transepidermal water loss and understand the resulting skin abnormalities due to negative gene control. Methods Searched scientific web pages, Pubmed, Science direct, Google Scholar, for recent (year: 2010 to 2020) experimental data. (N=7 scientific studies were analyzed) Results Relevance of these studies relates to major topics in the genetics of transepidermal water loss, but few concluded that genetic markers such as filaggrin, 9q34.3, and ALCAM correlates with transepidermal water loss. These genetic markers suggest that they can increase water diffusion and decrease when the markers are detected. It is crucial to understand how TEWL is controlled in order for sufficient barrier function. Conclusion The dependence on water regulator proteins such as aquaporins and tight junction proteins decreases as skin matures, and the level of these proteins and TEWL relate to gestation age. Molecular control of TEWL through such proteins is an indication of healthy skin. Further elaboration on these proteins and genes discussed should help understand their regulatory patterns to protect the stratum corneum.