Abstract
<p>Supplementary figure S2 (A) CAR expression in T cells after lentiviral transduction was analyzed by flow cytometry analysis. From left to right, non-transduced T cells as a control, T cells transduced with YK-BCMA BB-002 CAR vector. CAR expression was monitored by biotinylated goat anti-mouse and anti-human antibodies (Jackson ImmunoResearch Laboratories, Inc.), followed by APC-labelled streptavidin (BD Pharmingen). (B) Cytotoxicity as using BCMA-directed CAR T-cells co-cultured with HeLa-BCMA cells at various E.T. ratios (0.25:1, 0.5:1, 1:1, and 5:1, respectively). Compared with control T cells, BCMA-directed CAR T-cells demonstrated very strong cytotoxicity towards target cells, even at very low E:T ratios.</p>
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