Figure S1 to S15 from Involvement of Prokineticin 2–expressing Neutrophil Infiltration in 5-Fluorouracil–induced Aggravation of Breast Cancer Metastasis to Lung

Abstract

<p>Figure S1: 5-FU-induced increase in lung metastasis of TS/A. Figure S2: Effects of 5-FU treatment on cells infiltrating into lungs. Figure S3: Characterization of CD11b+Ly6G+ cells infiltrated into lung. Figure S4: 5-FU effects to expression of Cxcl1 and Cxcl2 in lung. Figure S5: Molecular mechanisms underlying 5-FU, CTX and DOX-induced Cxcl1 and Cxcl2 expression in 4T1 and TS/A cells. Figure S6: Molecular mechanisms underlying 5-FU-induced CXCL1, CXCL2, and CXCL8 expression in a human breast cancer cell line, BT-20 cells. Figure S7: Effects of 5-FU treatment on CD11b+Ly6G+ neutrophils in lungs. Figure S8: Reduction in 5-FU-induced increase in lung metastasis by Prokr1 deletion. Figure S9: Schematic demonstration on presumed cellular and molecular mechanisms underlying 5-FU-enhanced lung metastasis of breast cancer. Figure S10: Effect of 5-FU on cell senescence in 4T1 and TS/A cells. Figure S11: Effect of an ATM inhibitor, KU-60019, on Cxcl1 and Cxcl2 expression in 4T1 and TS/A cells. Figure S12: Effect of H2O2 on Cxcl1 and Cxcl2 expression in 4T1 cells. Figure S13: Relation of PROKR1 and PROK2 expression with the prognosis of breast cancer patients. Figure S14: Effect of Cxcl1, Cxcl2 and G-CSF on Prok2 expression in CD11b+Ly6G+ neutrophils. Figure S15: Effect of 5-FU on G-csf expression in lung tissue.</p>