Abstract

Fighting Ebola with ZMapp: spotlight on plant-made antibody.

Highlights

  • A large Ebola endemic is ongoing in West Africa

  • Ebola viruses are the infectious agent causing the Ebola virus disease (EVD). They belong to the genus Ebolavirus of the Filoviridae family and have been categorized into five known species: Ebola virus (EBOV, formerly Zaire Ebola virus), Bundibugyo virus (BDBV), Sudan virus (SUDV), Taï Forest virus (TAFV), and Reston virus (RESTV)

  • The 2014 Ebola outbreak is caused by Zaire EBOV, whose fatality rate is as high as 90%

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Summary

Introduction

According to the World Health Organization, as of August 19, the viral outbreak has led to 2240 suspected and confirmed cases and 1229 deaths in four countries: Guinea, Liberia, Nigeria, and Sierra Leone (http://www.cdc.gov/vhf/ ebola/outbreaks/guinea/index.html). The 2014 Ebola outbreak is caused by Zaire EBOV, whose fatality rate is as high as 90%. Direct contacts with body fluids of infected individuals are considered to be the main route of EBOV transmission (http://www.cdc.gov/vhf/ebola/transmission/index.html), whereas aerosol infection has not been reported clinically,

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