Fierul, feroptoza şi asocierea cu evoluţia tumorală şi potenţialul impact terapeutic

Abstract

This article aims at presenting the modern tendencies to redefine the role of iron into the normal and pathological metabolic processes, reminding the normal metabolic pathways of iron, and then compare the normal findings with pathological ones, mostly in cancers. One relatively new concept is ­“ferroptosis”, a different type of (cancer) death cell, intensely researched, at least in the past 11 years. All of these results could potentially have an impact in the better understanding of the metabolism of cancer cells and in the therapeutic area, as a practical ultimate endpoint.