Abstract
Spatial organization of biomolecules through liquid-liquid phase separation (LLPS) has been argued to be essential for cellular function but poses severe challenges for simulation and mathematical modelling due to the large numbers of molecules and interaction types involved. Field theory (FT) models of bio-LLPS, where molecular degrees-of-freedom are traded for a set of fluctuating fields, constitute a promising computational approach since the number of molecules in the system is not a limiting factor in simulation.
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