Abstract
Phytochemical investigation of the roots of Maytenus royleanus resulted into the isolation of a new cytotoxic triterpene ficusonic acid, 3β,21β-dihydroxyolean-12-en-29-oic acid, together with three known compounds, 3α,22β-dihydroxyolean-12-en-29-oic acid, salaspermic acid and orthosphenic acid, reported for the first time from this source. Their structures were established on the basis of extensive spectroscopic techniques. The cytotoxic activity of compound 3β,21β-dihydroxyolean-12-en-29-oic acid was evaluated against two cancer cell lines, PC-3 prostate and HeLa cervical cancer lines. 3β,21β-dihydroxyolean-12-en-29-oic acid showed weak activity against PC-3 (IC50 = 35.42 µmol L-1) however against HeLa (IC50 = 20.47 µmol L-1), its activity was moderate.
Highlights
The family Celastraceae is a large family of 90-100 genera and about 1300 species which are widely distributed in the world having a wide range of uses in folk medicine.[1]
The IR spectrum showed absorption bands at 3358, 3045 (C-H olefinic), 1760 and 1381 cm-1. 13C Nuclear magnetic resonance (NMR) and distortionless enhancement by polarization transfer (DEPT) spectra indicated a total of 30 carbons including seven tertiary methyls, nine methylenes, six methines and eight quaternary carbons (Table 1)
The chemical investigation of the roots of Maytenus royleanus resulted in the isolation of four compounds: 3β,21β-dihydroxyolean-12-en-29-oic acid (1), 3α,22β‐dihydroxyolean-12-en-29-oic acid (2), salaspermic acid (3) and orthosphenic acid (4)
Summary
The family Celastraceae ( called Chingithamnceae, Canotinceae, Goupiaceae and Siphonodentaceae) is a large family of 90-100 genera and about 1300 species which are widely distributed in the world having a wide range of uses in folk medicine.[1]. Large scale extraction of Maytenus royleana (13 kg) resulted into the isolation of one new (1, C30H48O4, m/z 472) and three known compounds [(2, C30H48O4, m/z 472), (3, C30H48O4, m/z 472) and (4, C30H48O5, m/z 488)] (Figure 1).
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