Ficus hispida Bark Extract Prevents Nociception, Inflammation, and CNS Stimulation in Experimental Animal Model.

Md Sariful Islam Howlader,Shubhra Kanti Dey,Arif Ahmed,Md Hemayet Hossain,Md Afjalus Siraj,Arpona Hira

doi:10.1155/2017/7390359

Abstract

Background. Ficus hispida is traditionally used in the ailment of pain, inflammation, and neurological disorders. The present study set out to evaluate the in vivo antinociceptive, anti-inflammatory, and sedative activity of the ethanol extract of Ficus hispida bark (EFHB). Methods. The antinociceptive activity of EFHB was evaluated by using acetic acid induced writhing, formalin, hot plate, and tail immersion methods in Swiss albino mice. Its anti-inflammatory activity was assessed by using carrageenan and histamine induced rat paw oedema test in Wister rats. The central stimulating activity was studied by using pentobarbital induced hypnosis, hole cross, and open field tests in Swiss albino mice. Results. EFHB demonstrated antinociceptive activity both centrally and peripherally. It showed 62.24% of writhing inhibition. It significantly inhibited licking responses in early (59.29%) and late phase (71.61%). It increased the reaction time to the thermal stimulus in both hot plate and tail immersion. It inhibited the inflammation to the extent of 59.49%. A substantial increase in duration of sleep up to 60.80 min and decrease of locomotion up to 21.70 at 400 mg/kg were also observed. Conclusion. We found significant dose dependent antinociceptive, anti-inflammatory, and sedative properties of EFHB in experimental animal models.

Highlights

Ficus hispida (Linn.) (Moraceae) is a medium sized tree generally known as Dumoor in Bangladesh
The samples were deposited at Bangladesh National Herbarium (BNH) and identified by the experts
Naloxone counteracts the antinociceptive activity of both extract of Ficus hispida bark (EFHB) and morphine (Table 5)

Summary

Introduction

Ficus hispida (Linn.) (Moraceae) is a medium sized tree generally known as Dumoor in Bangladesh It is a popular plant which is widely distributed throughout subcontinent including India and Bangladesh [1]. Pharmacological properties of the whole plant, fruit, root, and leaves of F. hispida have already been reported. The leaves and fruits have been reported for their analgesic activity in acetic acid-induced writhing model in mice [14]. The present study set out to evaluate the in vivo antinociceptive, anti-inflammatory, and sedative activity of the ethanol extract of Ficus hispida bark (EFHB). The antinociceptive activity of EFHB was evaluated by using acetic acid induced writhing, formalin, hot plate, and tail immersion methods in Swiss albino mice. EFHB demonstrated antinociceptive activity both centrally and peripherally We found significant dose dependent antinociceptive, anti-inflammatory, and sedative properties of EFHB in experimental animal models

Methods

Results

Conclusion