Abstract
Ficolin-2 triggers antitumor and anti-pathogen effects by activating antigen presenting cells and CD8+T cells
Highlights
Increasing studies have shown that ficolin-2 can bind to glycoproteins of pathogens including viral (Hepatitis C Virus, Influenza A virus and Human Immunodeficiency Virus) and virulent Mycobacterium tuberculosis (M.tb) and inhibit viral and bacterial infections[4,5,6,7,8,9,10] (Figure 1)
Lower ficolin-2 protein expression was found in the tissue samples of Hepatocellular Carcinoma (HCC) patients with HCC metastasis compared to nonmetastasis patients[13]
When early antigen-processing cells (APCs) and CD8+ T cells were depleted, mice exhibited no significant differences in tumor growth between the ficolin2-treated group and non-ficolin-2-treated group
Summary
Increasing studies have shown that ficolin-2 can bind to glycoproteins of pathogens including viral (Hepatitis C Virus, Influenza A virus and Human Immunodeficiency Virus) and virulent Mycobacterium tuberculosis (M.tb) and inhibit viral and bacterial infections[4,5,6,7,8,9,10] (Figure 1). Ficolin-2 binds tumor cells, macrophages and CD8+ T cells in vitro A recent report showed that ficolin-3 directly attacked cancer cells via a novel complement pathway[12].
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