Abstract
Here, we adapt the concept of transformational thermodynamics, whereby the flux of temperature is controlled via anisotropic heterogeneous diffusivity, for the diffusion and transport of mass concentration. The n-dimensional, time-dependent, anisotropic heterogeneous Fick's equation is considered, which is a parabolic partial differential equation also applicable to heat diffusion, when convection occurs, for example, in fluids. This theory is illustrated with finite-element computations for a liposome particle surrounded by a cylindrical multi-layered cloak in a water-based environment, and for a spherical multi-layered cloak consisting of layers of fluid with an isotropic homogeneous diffusivity, deduced from an effective medium approach. Initial potential applications could be sought in bioengineering.
Highlights
This report aims to target already-existing systems that could enable the use of cloaking concepts in order to achieve control of three-dimensional processes, using coated spheres consisting of concentric layers of homogeneous isotropic diffusivity
We show numerically that control can be achieved in three-dimensional processes, using coated spheres consisting of concentric layers of homogeneous isotropic diffusivity, which mimic certain anisotropic heterogeneous diffusivity
We would like to use similar analogies between diffusion of heat and concentration of chemical species to propose an original strategy towards cloaking in bioengineering/chemical engineering
Summary
This report aims to target already-existing systems that could enable the use of cloaking concepts in order to achieve control of three-dimensional processes, using coated spheres consisting of concentric layers of homogeneous isotropic diffusivity. Various applications already implicate the use of concentric bilayered vesicles, one example being liposomes used for drug delivery [1]. Liposomes are concentric bilayered vesicles in which an aqueous volume containing a water-soluble drug is enclosed by a membranous lipid bilayer composed of natural or synthetic phospholipids. Stealth and other liposomes use the concept of ‘invisibility’ in order to hide and evade the immunosystem by coupling water-soluble polymers to the lipid heads. Other alternative applications to liposomes are nanoparticles based on solid lipids (SLNs). These are composed of SLNs stabilized with an emulsifying layer in an aqueous dispersion. This has benefits such as drug mobility. The release of the drug-enriched core of SLN is based on Fick’s first law of diffusion [5,6,7]
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