Abstract
Fibulin-5 has recently been considered as a potential tumor suppressor in human cancers. Several studies have shown that it is down-regulated in a variety of tumor types and inhibits tumor growth and metastasis. This study was aimed to investigate the clinical significance of fibulin-5 in glioma and its role in cell proliferation and invasion. We found that the expression of fibulin-5 in glioma tissues was significantly lower than those in normal brain (NB) tissues. Negative expression was significantly correlated with advanced clinical stage (grade III+IV). Furthermore, Fibulin-5 negative expression was correlated with a shorter overall survival of glioma patients. Multivariate Cox repression analysis indicated that fibulin-5 was an independent factor for predicting overall survival of glioma patients. Overexpression obviously inhibited cell proliferation in U251 and U87 cells. Furthermore, it significantly reduced the number of migrating and invading glioma cells. In conclusion, impaired expression of fibulin-5 is correlated with the advanced tumor stage in glioma. Otherwise, Fibulin-5 is an independent prognostic marker for predicting overall survival of glioma patients. Mechanistically, it may function as a tumor suppressor via inhibiting cell proliferation and invasion in gliomas.
Highlights
Malignant glioma is the commonest malignant tumor in brain (Li et al, 2014b)
Expression of Fibulin-5 in glioma and normal brain (NB) tissues To determine the expression of Fibulin-5 in glioma specimens, we detected the levels of Fibulin-5 expression in 86 collected glioma tissues and 20 collected NB tissues using immunohistochemical staining
Clinical significance of Fibulin-5 in glioma cases To investigate the clinical significance of Fibulin-5 in glioma, we analyzed the correlation between Fibulin-5 expression and clinicopathological parameters in glioma
Summary
Malignant glioma is the commonest malignant tumor in brain (Li et al, 2014b). The Fibulins is an old protein family, which is conserved in both worms and humans (Hwang et al, 2013). Fibulins are structurally consisting with a globular Fibulin-type module in C-terminal and calcium-binding epidermal growth factor (EGF)-like modules (Hwang et al, 2013). The expression of Fibulin-5 is impaired in various human cancer tissues including renal cell carcinoma, bladder urothelial carcinoma, prostate cancer, lung cancer, colorectal cancer and hepatocellular carcinoma (Wlazlinski et al, 2007; Yanagisawa et al, 2009; Hu et al, 2011; Ohara et al, 2011; Tu et al, 2014). The clinical significance of Fibulin-5 and its function in human glioma is poorly understood
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