Abstract
New nanocomposite membrane was fabricated by electrospinning. The nanocomposite combines a glass and hydroxyapatite (HA). This research proposed the incorporation of glass to counteract the brittleness of HA in a composite formed by coaxial fibers which will be used for bone replacement. Calcium phosphate ceramics are used widely for dental and orthopedic reasons, because they can join tightly through chemical bonds and promote bone regeneration. Precursors HA and SiO2 were synthetized through the sol-gel method and then incorporated into a polymeric PVP matrix; later they were processed by coaxial electrospinning to obtain fibers with an average diameter of 538 nm which were characterized with techniques such as Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy, Differential Thermal Analysis and Scanning Electron Microscopy. Chemical and physical characterization of the membranes evidenced fibers in a coaxial disposition with a glass core and hydroxyapatite cover. The micro-porous fibers have many potential uses in the repair and treatment of bone defects, drug delivery and tissue engineering. Through ATR-FTIR and SEM-EDX analysis the presence of characteristic chemical groups, the fiber composition and microstructure were determined.
Highlights
Until very recently the repair of the skeletal system was performed with the use of bone grafts, the difficulty of obtaining such materials from natural sources and donors allowed the introduction of non-biological materials which can be obtained through synthetic processes while they are less likely to produce antigenic reactions (Dinarvand et al, 2011; Http://www.granthaalayah.com ©International Journal of Research - GRANTHAALAYAH [39][López et al, Vol.5 (Iss.2): February, 2017]ISSN- 2350-0530(O), ISSN- 2394-3629(P)ICV (Index Copernicus Value) 2015: 71.21IF: 4.321 (CosmosImpactFactor), 2.532 (I2OR)Roveri et al, 2003)
Precursors HA and SiO2 were synthetized through the sol-gel method and incorporated into a polymeric PVP matrix; later they were processed by coaxial electrospinning to obtain fibers with an average diameter of 538 nm which were characterized with techniques such as Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy, Differential Thermal Analysis and Scanning Electron Microscopy
In the coaxial fibers manufactured with SiO2 flows of 0.8 and 0.4 mL/h there were contrast areas arranged longitudinally of what is presumed to be SiO2 encapsulated in hydroxyapatite
Summary
Until very recently the repair of the skeletal system was performed with the use of bone grafts, the difficulty of obtaining such materials from natural sources and donors allowed the introduction of non-biological materials which can be obtained through synthetic processes while they are less likely to produce antigenic reactions (Dinarvand et al, 2011; Http://www.granthaalayah.com ©International Journal of Research - GRANTHAALAYAH [39][López et al, Vol. (Iss.2): February, 2017]ISSN- 2350-0530(O), ISSN- 2394-3629(P)ICV (Index Copernicus Value) 2015: 71.21IF: 4.321 (CosmosImpactFactor), 2.532 (I2OR)Roveri et al, 2003). Hydroxyapatite (Ca10(PO4)6(OH)2) is the primary mineral component of human bones and teeth, it is a bioceramic, and can be obtained through a variety of chemical reactions such as hydrolysis or sol-gel method. This compound has been researched for the replacement of hard tissue, there are several characteristics that restrict its use in biomedical applications: absence of antimicrobial properties, brittleness and limited contact with the host tissue (Basu and Balani, 2011). The use of silicate as a reinforcement component in flexible membranes has been researched with success improving the mechanical characteristics of such materials (Tian et al, 2015)
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