Abstract
Rotary jet spinning (RJS) and electrospinning are techniques to obtain fibrous scaffolds. RJS is a simple method, which fabricates three-dimensional fibers by exploiting a high-speed rotating nozzle, creating a polymer jet which stretches until solidification, and does not require high voltage. In opposite, electrospinning technique needs the presence of an external electric field to create fiber from the polymeric jet solution. This article investigates both processes using two different biocompatible polymers: Poly(L-lactic acid) (PLLA) and Poly(e-caprolactone) (PCL). Samples were characterized by scanning electron microscopy, thermogravimetric analysis, differential scanning calorimeter, and Fourier-transform infrared spectroscopy. Morphological observations showed the efficiency of both techniques in obtaining nanofibers. Thermal analyses of data indicate immiscible property of different blends and the total solvent evaporation. In vitro cytocompatibility test showed that RJS and electrospinning samples exhibited good cytocompatibility. Based on these results, it may be concluded that the fibers obtained with both technologies are non-cytotoxicity and with good biocompatibility, and might be suitable for applications as scaffold for cell growth.
Highlights
Since 1934, electrospinning has been used as an important method to obtain nano-/microfibers
This study focuses on the production of fibrous scaffolds using the Rotary jet spinning (RJS) and electrospinning processes, aiming to compare the techniques, fibrous, and polymers
Samples were characterized by scanning electron microscopy (SEM), thermogravimetric analysis (TGA), differential scanning calorimeter (DSC), and Fourier-transform infrared spectroscopy (FTIR)
Summary
Since 1934, electrospinning has been used as an important method to obtain nano-/microfibers. It is based in the effect of electrostatic force on liquids, which spin polymer solutions or melts into whipped jets, producing continuous fibers with controlled diameter and orientation[1]. Despite many approaches, electrospinning still presents many drawbacks, mainly low productivity and electrical field requirements 2. Rotary jet spinning (RJS) represents an available, cost effective process, and an efficient alternative method, with a 100-fold higher fiber production rate over that achievable by electrospinning. RJS eliminates the requirement of an electric field or of a charged solution 3. The system fabricates three-dimensional aligned or random nano-/microfibers by exploiting a high-speed rotating nozzle, to form a polymer jet that undergoes stretching before solidification 4
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