Abstract
Malignant transformation of fibrous dysplasia is rare, occurring in less than 1% of cases with a mean lag period of 13.5 years. We report a case of Osteogenic Sarcoma with chondroid differentiation in a pre-existing Fibrous Dysplasia occurring within one year of surgical resection and without any history of exposure to radiation. To the best of our knowledge and extensive search of literature, malignant transformation of Fibrous Dysplasia in such a short period of time, and without history of radiation exposure has never been reported from India.Journal of Pathology of Nepal (2012) Vol. 2, 335-337DOI: http://dx.doi.org/10.3126/jpn.v2i4.6891
Highlights
Fibrous dysplasia (FD) is a benign bone disorder of an unknown etiology, uncertain pathogenesis and diverse histopathology.[1]
We report a case of Osteogenic sarcoma with chondroid differentiation in a pre-existing Fibrous Dysplasia occurring within one year of surgical resection and without any history of exposure to radiation
Histopathological diagnosis of low grade osteogenic sarcoma of mandible with chondroid differentiation arising from pre-existing FD was made
Summary
Fibrous dysplasia (FD) is a benign bone disorder of an unknown etiology, uncertain pathogenesis and diverse histopathology.[1]. Monostotic and craniofacial lesions have the greatest potential for malignant transformation.[2] We report a case of Osteogenic sarcoma with chondroid differentiation in a pre-existing Fibrous Dysplasia occurring within one year of surgical resection and without any history of exposure to radiation.
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