Abstract
Retroperitoneal fibrosis (RPF) associated with chronic use of ergotamine is a very rare disorder. We report a 45-year-old woman who presented with a RPf after using, almost daily for 23 years, ergotamine tartrate for migraine relief. FRP presented as a chronic inflammatory state, anemia, abdominal and lumbosacral pain and a hypogastric mass. A CT-Scan showed a periaortic mass and left hydronephrosis. A percutaneous biopsy was obtained and the patient was subjected to a surgical ureterolysis and tissue resection. The biopsy confirmed the presence of RPf. Due to persistent symptoms and increase in the volume of periaortic tissue, treatment with colchicine 1 mg/day and defazacort 30 mg/day was started, resulting in a rapid disappearance of symptoms, disappearance of inflammation and a significant reduction in the volume of the periaortic tissue. The patient remains in complete remission after 29 months of follow up.
Highlights
Retroperitoneal fibrosis (RPF) associated with chronic use of ergotamine is a very rare disorder
La serotonina es una sustancia que promueve la fibrosis tanto a nivel experimental como en humanos, afectando al tejido pulmonar, válvulas cardíacas, endocardio, arterias y espacio retroperitoneal
Effectiveness of colchicine therapy in 4 cases of retroperitoneal fibrosis associated with autoinflammatory diseases
Summary
Retroperitoneal fibrosis (RPF) associated with chronic use of ergotamine is a very rare disorder. Recientemente se publicó una serie clínica en que se utilizó colchicina (como agente antifibrótico) asociada a dosis reducidas de corticoides en pacientes con FRP idiopática (FRPI) con buenos resultados, escasos efectos secundarios y ausencia de recurrencias[8]. Posteriormente, un scanner abdominal mostró una masa retroperitoneal e hidronefrosis izquierda que hizo sospechar un linfoma.
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