Abstract
In this preliminary survey, twenty-six compounds, related in one way or another to dicetyl(di- n-hexadecyl)phosphate, were compared with this substance as to tissue fibrosing activity by subcutaneous injections in the rat. Only dialkylphosphates (and the single alkylborate used) with a chain length of sixteen or eighteen carbon atoms were active. The only substance with unsaturated alkyl chains, dioleyl(C 18)phosphate, was inactive. Dicholesteryl-phosphate and phosphite were not active. None of the phosphites (di- or tri-) was active. Dicetylborate produced less flbrosis than the phosphate and this was accompanied by marked eosinophilia and subsequent encapsulated necrosis. Dioctadecyl phosphate was indistinguishable in these experiments from dicetyl phosphate.
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