Abstract
The adhesion of cells to the extracellular matrix (ECM) protein, fibronectin, is important in the regulation and coordination of such complex processes as cell growth, migration, differentiation, and ECM organization. The deposition of fibronectin into the ECM is a cell-dependent process that is normally tightly regulated to ensure controlled matrix deposition. Increased deposition of fibronectin and collagen into the subepithelial space of the airways is observed in all forms of asthma and occurs early in the progression of the disease. Experimental evidence suggests a model in which fibronectin matrix accumulation contributes to the progression of asthma by altering both the structural properties of the airways and the functional properties of cells of the airway wall.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
