Fibrodysplasia ossificans progressiva-like in a cat

L.Z Crivelenti,A.M Brum,S Borin,D.K Honsho

doi:10.1590/s0102-09352012000200015

Abstract

Fibrodysplasia ossificans progressiva-like (FOP-like) was diagnosed in a young Brazilian cat presenting progressive lameness, pain upon manipulation and inability to extend the hind limbs. Due to poor response to medication described in the literature, only orchiectomy and confinement of the patient were recommended. The patient described here has been observed for four years and the animal is currently in fair condition despite the movement restrictions.

Highlights

The pathogenesis of Fibrodysplasia ossificans progressiva (FOP) in humans is associated with mutations in chromosome 4q2-31 which seems to modify the expressivity of bone morphogenetic protein 4 (BMP-4), a factor which is probably involved in maintenance and expansion of ectopic ossification (Campos et al, 2005; Kan et al, 2004)
Information about fibrodysplasia ossificans progressiva-like (FOP-like) in veterinary medicine is limited due to the small number of reports regarding the natural occurrence of ectopic ossification in animals (Guilliard, 2001; Kaplan et al, 2005; Asano et al, 2006)
An early and correct diagnosis of FOP is essential for the establishment of appropriate management of the patient

Summary

Introduction

Fibrodysplasia ossificans progressiva (FOP), known as myositis ossificans progressiva or Münchmeyer's disease (Campos et al, 2005), is a rare disease in humans (Palhares and Leme, 2001) and animals (Guilliard, 2001; Kaplan et al, 2005; Asano et al, 2006).In humans, it exhibits autosomal dominant inheritance with variable expressivity, despite the fact that many cases are sporadic (Palhares and Leme, 2001). Fibrodysplasia ossificans progressiva (FOP), known as myositis ossificans progressiva or Münchmeyer's disease (Campos et al, 2005), is a rare disease in humans (Palhares and Leme, 2001) and animals (Guilliard, 2001; Kaplan et al, 2005; Asano et al, 2006).

Results

Conclusion