Fibroblasts: Heterogeneous Cells With Potential in Regenerative Therapy for Scarless Wound Healing.

Jun-Jie Wu,Ying-Ying Teng,Jun-Xing Ye,Zhong-Hua Chen,Zi-Li Sun,Xia Li,Kai-Wen Zhang,Rui-Sheng Xu,Feng-Lai Yuan,Ming-Li Zou,Si-Yu Liu,Yuan Jia,Xiao-Yu Tang

doi:10.3389/fcell.2021.713605

Abstract

In recent years, research on wound healing has become increasingly in-depth, but therapeutic effects are still not satisfactory. Occasionally, pathological tissue repair occurs. Influencing factors have been proposed, but finding the turning point between normal and pathological tissue repair is difficult. Therefore, we focused our attention on the most basic level of tissue repair: fibroblasts. Fibroblasts were once considered terminally differentiated cells that represent a single cell type, and their heterogeneity was not studied until recently. We believe that subpopulations of fibroblasts play different roles in tissue repair, resulting in different repair results, such as the formation of normal scars in physiological tissue repair and fibrosis or ulcers in pathological tissue repair. It is also proposed that scarless healing can be achieved by regulating fibroblast subpopulations.

Highlights

People suffer from a diverse range of injuries from the environmental, psychological and emotional injuries and physical injuries
Studies have shown that fibroblasts in the dermis of the skin can be divided into papillary fibroblasts (Fps), reticular fibroblasts (Frs), and dermal-subcutaneous junction fibroblasts (F-DHJs) (Haydont et al, 2019, 2020)
Research has found that cells from the healing dermal deep layer exhibit a phenotype resembling that of myofibroblasts in terms of expression of a-SMA and reticular markers that are associated with myofibroblasts, such as calponin 1, peroxisome proliferator-activated receptor gamma and transglutaminase 2, which directly corresponds to Frs and F-DHJs from the deep dermis and the junction (Ali-Bahar et al, 2004; Wang et al, 2008; Kulkarni et al, 2011)

Summary

Introduction

People suffer from a diverse range of injuries from the environmental, psychological and emotional injuries and physical injuries. Studies have shown that fibroblasts in the dermis of the skin can be divided into papillary fibroblasts (Fps), reticular fibroblasts (Frs), and dermal-subcutaneous junction fibroblasts (F-DHJs) (Haydont et al, 2019, 2020).

Results

Conclusion