Abstract
Major depressive disorder (MDD) is one of the most serious diseases and now becomes a major public health problem in the world. The pathogenesis of depression remains poorly understood. Fibroblast growth factors (FGFs) belong to a large family of growth factors that are involved in brain development during early periods as well as maintenance and repair throughout adulthood. In recent years, studies have found a correlation between the members of the FGF system and depression. These signaling molecules may be expected to be biomarkers for the diagnosis and prognosis of MDD, and may provide new drug targets for the treatment of depression. Here, we reviewed the correlation between some members of the FGF system and depression.
Highlights
Fibroblast Growth Factors in DepressionMajor depressive disorder (MDD) is one of the most serious diseases and becomes a major public health problem in the world
Specialty section: This article was submitted to Neuropharmacology, a section of the journal Frontiers in Pharmacology
In chronic unpredictable mild stress (CUMS) mice, FGF2 increased the phosphorylation of extracellular signal-regulated kinase (ERK) and AKT via binding to Fibroblast growth factor receptor 1 (FGFR1), which up-regulated the expression of Bcl-2, leading to decreased caspase-3 levels
Summary
Major depressive disorder (MDD) is one of the most serious diseases and becomes a major public health problem in the world. Fibroblast growth factors (FGFs) belong to a large family of growth factors that are involved in brain development during early periods as well as maintenance and repair throughout adulthood. Studies have found a correlation between the members of the FGF system and depression. These signaling molecules may be expected to be biomarkers for the diagnosis and prognosis of MDD, and may provide new drug targets for the treatment of depression. Fibroblast growth factors (FGFs) belong to a large family of growth factors that are involved in brain development during early periods as well as maintenance and repair throughout adulthood (Terwisscha van Scheltinga et al, 2013). We mainly concentrated on the reported depression-related FGF system members, including FGFR1, FGF2, FGF9, FGF21, and FGF22
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