Abstract
Fibroblast growth factors (FGFs) make up a large family of multifunctional polypeptide growth factors of which there are 22 distinct members. The FGF family shows a high affinity for heparin and also interacts with FGF receptors. FGF can be classified into subgroups according to structures, biochemical properties, and expression. Members of FGF family have been identified in a variety of organisms, and they play a significant role in many cellular processes including mitogenesis differentiation, migration, and cell survival. However, it also has the potentiality to induce oral neoplasms, and various FGFs can be used for therapeutic purpose as well. This review discusses the basic mechanism for FGF action, and their receptors, various functions of FGFs in normal development, their role in cancer formation along with oral diseases and treatment.
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