Abstract
Introduction: Liver transplantation, the only curative treatment for end-stage liver failure, is limited by the availability of donor organs; therefore, other potential methods of hepatocyte replacement, such as hepatic progenitor cell (HPC) transplantation, require investigation. Fibroblast Growth Factors (FGFs) are required for induction of the hepatic bud from the foregut endoderm at the initial stages of hepatogenesis. We recently showed that FGF10 promotes HPC survival and proliferation via β-catenin activation through receptor FGFR2IIIb activation.
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