Abstract
Fibroblast growth factor (FGF), epidermal growth factor (EGF) and insulin added in combination to the culture medium in which normal human muscle was cultured caused a 4.0-fold ( P < 0.005) increase of the total number of nicotinic acetylcholine receptors (AChRs) and a 4.5-fold ( P < 0.001) increase in AChR aggregation. Individually, only FGF caused a 3.0-fold increase ( P < 0.005) in AChR aggregation, without influencing the total number of AChRs. To the contrary, insulin alone caused a 2.0-fold increase ( P < 0.05) in the total number of AChRs without influencing AChR aggregation. These findings show that these three polypeptide growth factors exert a neuronal-like influence on cultured human muscle in regard to AChRs.
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