Fibroblast Growth Factor 19 Levels Predict Subclinical Atherosclerosis in Men With Type 2 Diabetes.

Jingyi Hu,Weili Tang,Yang Xiao,Aimin Xu,Xiaoyan Chen,Zhiguang Zhou,Zhiwen Liu,Zubing Mei,Pengcheng Zhou,Yue Tong

doi:10.3389/fendo.2020.00282

Abstract

Objective: Fibroblast growth factor 19 (FGF19) plays an indispensable role in regulating bile acid, glucose, and lipid metabolism, and alterations of its circulating concentration is associated with the development of type 2 diabetes (T2D). Atherosclerosis is directly related to the death-deriving diabetic macroangiopathy in T2D, yet relationships between FGF19 and atherosclerosis in T2D remain unclear. The aim of this study was to investigate the association of circulating FGF19 levels with the development of subclinical atherosclerosis (subAS) in patients with T2D in a 3-year prospective study.Methods: In the present study, 153 newly diagnosed T2D patients without subAS were recruited at baseline, and 137 of them completed a 3-year follow-up. FGF19 levels were measured in fasting serum samples collected at baseline and the third-year visits. Carotid, femoral, and iliac intima-media thickness (IMT) were detected by high-resolution B-mode ultrasound to determine the presence of subAS. Logistic regression analysis was applied to assess the relationship between serum FGF19 and subAS in patients with T2D.Results: At baseline, serum FGF19 levels were positively correlated with carotid IMT and iliac IMT in men (r = 0.239, P = 0.036; r = 0.309, P = 0.006). At the 3-year follow-up, 25 out of 153 patients developed subAS, and FGF19 levels in men were higher in the subAS group than in the non-subAS group [202.7 (177.9–373.6) vs. 133.4 (85.6–171.3) pg/ml, P = 0.028]. Furthermore, in men, higher baseline levels of FGF19 were independently associated with a greater risk of subAS at year 3 in patients with T2D with an odds ratio (OR) of 4.798 per 1 standard deviation (SD) of the FGF19 concentration [OR = 4.798 (95% CI, 1.680–13.706), P = 0.003]. Baseline FGF19 levels yielded an area under the receiver operating characteristic curve of 0.769 to predict the development of subAS at year 3 in men with T2D.Conclusions: Serum FGF19 levels could help in predicting the development of atherosclerosis in men with T2D.

Highlights

Diabetes mellitus is currently burdening approximately 463 million people worldwide with booming healthcare cost and plummeting disability adjusted life year [1,2,3]
At baseline, serum Fibroblast growth factor 19 (FGF19) levels were positively correlated with carotid intimamedia thickness (IMT) and iliac IMT in men (r = 0.239, P = 0.036; r = 0.309, P = 0.006)
In men, higher baseline levels of FGF19 were independently associated with a greater risk of Subclinical atherosclerosis (subAS) at year 3 in patients with type 2 diabetes (T2D) with an odds ratio (OR) of 4.798 per 1 standard deviation (SD) of the FGF19 concentration [OR = 4.798, P = 0.003]

Summary

Introduction

Diabetes mellitus is currently burdening approximately 463 million people worldwide with booming healthcare cost and plummeting disability adjusted life year [1,2,3]. Diabetic macroangiopathy, which is characterized by atherosclerosis, is the most severe diabetic complication, which makes major contributions to diabetic mortality and morbidity [4]. Atherosclerosis is the reformation of blood vessels through the accumulation of lipids and redox signaling induction of factors in the arterial wall, which could result in rupture and stenosis in arteries and subsequent death-deriving processes [5]. Subclinical atherosclerosis (subAS) is an early indicator of the development of atherosclerosis, which could be assessed by increased intimamedia thickness (IMT) of arteries. This early identification could be conducive to early intervention and treatment, preventing further development of cardiovascular disease [6, 7]

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Conclusion