Abstract
Abstract Background The aim of this study was to investigate the importance of fibrinopeptide-A and fibrinopeptide-B, which occur during the formation of D-dimer, the most commonly used laboratory parameter, in the early diagnosis of acute mesenteric ischemia (AMI). Materials and methods This experimental study was performed in 30 male pathogen-free Wistar albino rats. The experimental animals were divided into 3 equal groups: Control group (n = 10), Sham group (n = 10) and Ischemia group (n = 10). Blood samples were taken 0, 1, 3, and 6 h after the simulation of mesenteric ischemia. Results Fibrinopeptide-A and fibrinopeptide-B levels increased significantly in the first 6 h in the ischemic group, similar to the increase in D-dimer levels. The statistical change between 0, 1, 3 and 6 h was more significant for fibrinopeptide-A and fibrinopeptide-B. Conclusion Fibrinopeptide-A and fibrinopeptide-B may be markers that can be used for early diagnosis of mesenteric ischemia, early diagnosis is highly important for decreasing mortality and morbidity.
Highlights
Acute mesenteric ischemia (AMI) has a poor prognosis when accompanied by concomitant diseases
Fibrinopeptide-A and fibrinopeptide-B may be markers that can be used for early diagnosis of mesenteric ischemia, early diagnosis is highly important for decreasing mortality and morbidity
D-dimer, lactate, neopterin and lactate dehydrogenase (LDH) values were investigated in these studies, and concluded that together with radiological examinations, they might help in the early diagnosis of acute mesenteric ischemia (AMI) [12, 13]
Summary
Acute mesenteric ischemia (AMI) has a poor prognosis when accompanied by concomitant diseases. Neopterin, creatine phosphokinase (CPK), lactate dehydrogenase (LDH), amylase, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and leukocytes levels have been increased according to intestinal wall changes. This elevation was significant at 6–12 h after the occlusion of superior mesenteric arter (SMA) [10, 11]. The aim of this study was to investigate the importance of fibrinopeptide-A and fibrinopeptide-B, which occur during the formation of D-dimer, the most commonly used laboratory parameter, in the early diagnosis of acute mesenteric ischemia (AMI). Blood samples were taken 0, 1, 3, and 6 h after the simulation of mesenteric ischemia
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