Abstract
To evaluate thrombin generation and platelet activation in pre-eclampsia we have measured fibrinopeptide A (FPA) and beta-thromboglobulin (BTG) by radioimnunoassay in patients with this disorder and have compared them to patients with essential hypertension of pregnancy and normal controls. In 10 patients with pre-eclampsia significantly elevated levels were found of FPA (8.3 ± 4.3 ng/ul; mean normal 1.6 ± 0.8ng/μl, p<0.01) and of BTG (51.9 ± 16 ng/μl; mean normal 31 ± 16 ng/μl, p<0.01). In 5 patients with pregnancy and essential hypertension the levels of FPA (5.65 ± 2.2 ng/μl, p<0.01) were lower than in pre-eclampsia but were still significantly elevated. BTG (37 ± 2.5 ng/μl) was not significantly increased in these patients. These results are consistent with increased thrombin generation and platelet release in preeclampsia. In pre-eclampsia there is evidence of intravascular coagulation which occurs to a greater degree than in pregnant patients with comparable raised blood pressure due to essential hypertension. Serial FPA measurements may prove useful in monitoring the development and treatment of pre-eclampsia.
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