Abstract
23 women who had been receiving 150 mg doses of depot medroxyprogesterone acetate every 3 months for 1 year were studied to determine the fibrinolytic activator content of vessel walls and individual response of fibrinolytic activity to venous occlusion. Amenorrhea occurred in most of the patients. Fibrinolytic activity and resuspended euglobulin precipitate on unheated fibrin plates were measured in venous stasis. Fibrinolytic activity was measured on venous biopsy specimens by the histochemical method of Todd modified and graded according to Pandolfi Astedt and Nilsson. The immunochemical method of Nilehn was used for determining fibrin degradation products. Histochemical determination of fibrinolytic activity showed a similarity between treated women and controls. Fibrinolytic activity to venous occlusion as measured on fibrin plates was also similar. No significant decrease in fibrinolytic activity was demonstrated for treated group (p>.05) and no fibrin degradation products were found. Contraceptive preparations containing progestogens alone are recommended for women with a history of thrombosis or predispostion to thrombosis.
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