Abstract
The fibrinolytic activity (FA) in immature ovaries of rats was compared with that of golden hamsters on days 3 and 4 after stimulation with pregnant mares' serum gonadotrophin (PMSG). In addition, FA of immature PMSG-stimulated rats was compared with that of adult rats 18 days after hypophysectomy. By means of the fibrin slide method, FA was localized in serial sections and evaluated semiquantitatively. On PMSG day 3, FA occurred in preovulatory follicles and developing corpora lutea. On PMSG day 4, FA was mostly localized in medullary vessels. This was also the case for hypophysectomized rats. While both species showed a comparably high FA on PMSG day 3, hamsters had a lower FA than rats on PMSG day 4. Similar low FA values were obtained in hypophysectomized rats. Non-vascular FA localization may be attributed to granulosa and thecal cells of preovulatory follicles and to luteinizing cells of developing corpora lutea. Vascular FA localization is ascribed to capillary sprouting in these two structures and to medullary vessels.
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