Abstract
static factors, particularly fibrinogen, in atherosclerosis and its complications has gained considerable interest. Since the early 1980s, several extensive prospective observational studies have convincingly demonstrated that fibrinogen is a powerful, independent marker for cardiovascular diseases in non-diabetic subjects [1], while our knowledge on the impact of fibrinogen as a cardiovascular risk factor in diabetes mellitus is still incomplete. Moreover, another important question is whether fibrinogen promotes atherosclerosis and cardiovascular diseases in diabetes, or does it increase in plasma due to the presence of atherothrombotic lesions.
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