Abstract
In a 64‐year‐old man several thrombo‐embolic episodes occurred in spite of oral anticoagulant treatment with Thrombotest values below 10%. Normalization of a low plasma fibrinogen, cryofibrinogen and the ethanol gelation test during heparin treatment, suggested chronic intravascular coagulation several weeks prior to the recognition of a pancreatic carcinoma. N‐terminal analysis of the clottable plasma proteins established that about 11 % of the plasma fibrinogen existed as soluble fibrin in plasma. Such a large amount of soluble fibrin suggests the joint action of thrombin and other proteases on the clottable proteins in vivo.
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