Abstract
Total knee arthroplasty is associated with a significant postoperative blood loss even without any form of perioperative anticoagulation. The potential role of QUIXIL(®), a fibrin sealant used in orthopaedic surgery to control blood loss and avoid blood transfusions in patients undergoing total knee arthroplasty was evaluated in a prospective randomized trial with twenty-four patients diagnosed with primary osteoarthritis of the knee. Results showed that application of 2ml QUIXIL(®) adds costs to treatment without reducing the number of transfused red blood cell counts and postoperative haemoglobin loss. However, significant lower levels of postoperative fluid loss (P=0.026) was detected in QUIXIL(®) treated patients. Regarding cost effectiveness and benefit no indication for the use of 2ml QUIXIL(®) fibrin sealant in standard knee arthroplasty could be proofed statistically.
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