Abstract
Abstract Abstract #4139 Background
 The most frequent postoperative complication after axillary limph node dissection is the axilary seroma (AS) formation. Currently accepted practice includes insertion of one or more drainage system for fluid evacuation. Several methods have been proposed to decrease AS formation, such as closed suction catheters, shoulder immobilisation, tetracycline sclerotherapy, talc podrage and closure of dead space; however no of them have reduced the incidence of AS. Seromas are associated with wound infection, wound dehiscence and skip flap necrosis, which prolong the recovery and can extend patient´s stay in Hospital.
 The aim of this prospective randomized controlled trial was to evaluate the efficacy of fibrin sealant (FS) on the prevention of AS.
 Material and Methods
 Sixty-two patients undergoing axillary lymph node dissection were randomized to treatment with drainaje alone (arm A, n=49), drainage plus FS (arm B, n=12), or FS alone (arm C, n=53). Arm B was cancelled after primary results. Efficacy was evaluated in terms of lengh of hospital stay, volumen of fluid drainage and rate of wound related complications (seroma, hematoma, infection, dehiscence) in each arm.
 Results
 No significative differences are detected neither type of surgery, nor histlogycal characteristics.
 
 The mean result is a difference of almost minus 3 days in postoperative stay in the FS group.
 
 Conclusions
 1- Application of fibrin sealant reduces the amount of serosanguinous drainage and the length of postoperative stay in patients who have undergone axillary lymph node dissection.
 2- Fibrin sealant allows to avoid the insertion of an axillar drainage system
 3- It is very important the correct preparation and application of the fibrin sealant and it should be performed by a qualified surgeon.
 4- Future clinical trials toasses the role of fibrin sealant seroma are warranted. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 4139.
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