Fibrin sealant as a delivery vehicle for cells, antibiotics, growth factors, and painkillers

Abstract

Fibrin sealant has vast uses in surgical settings for both cellular and noncellular delivery. Some advantages include biocompatibility, ability to support cell attachment, and controlled degradation rate. There are many clinical applications, from wound healing to improving bone defects to being used as an adjunct to surgery. It can also serve as a suitable delivery vehicle for cells, steroids, antibiotics, growth factors, chemotherapeutic agents, and painkillers. The composition of fibrin sealant can be altered to allow for controlled release, making it an attractive delivery system. Lastly, a wound healing model with 2 defects in the collagen construct may serve as a future application that utilizes fibrin sealant as a delivery system. This review highlights different uses of fibrin sealant as a delivery vehicle for cells, steroids, antibiotics, chemotherapeutic agents, growth factors, and painkillers