Abstract
Chinese hamster ovary (CHO) cells attach to fibrin with a round morphology and differentiate into stretched form when cell density increases. This morphological differentiation is accelerated and accentuated by striking elongation following the addition of dibutyryl cyclic AMP (db-cAMP) or cholera toxin (CT). In contrast to the prompt effect within 2–4 h after db-cAMP, there is a characteristic lag in the onset of CT effect. CHO cell attachment to fibrin was substantially more resistant to release by EDTA or EGTA than were cells attached to plastic. While cell attachment to fibrin could be gradually released by EDTA, adherence was relatively resistant to release by EGTA, suggesting that Mg 2+ may be important in cell adherence to fibrin.
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