Abstract
The BioCAT undulator-based beamline at the Advanced Photon Source (APS), Argonne IL, USA is a state-of-the-art instrument for biological noncrystalline diffraction and X-ray absorption spectroscopy that is generally available to the international scientific community. The design features of this instrument and the unique source properties of the APS allow collection of fibre diffraction patterns of exceptional quality from complex, weakly diffracting biological systems. The small focal spots achievable with this instrument (~40 x 200 microns) has allowed excellent discrimination of fine detail in fibre patterns from muscle and connective tissue as well as detection of weak diffraction features in the presence of large backgrounds. The high X-ray flux of the instrument (~1.5 x 1013 photons/s at 12 keV) permits dynamical experiments on these systems with very fast time resolution. Letters 475, 11-16. [17] Boehm, M. K., Woof, J. M., Kerr, M. A., Perkins, S. J. (1999) J. Mol. Biol. 286, 1421-1447. [18] Aslam, M., Perkins, S. J. (2001) Submitted.
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