Abstract
Previous studies have demonstrated that 3D myocardial fiber maps of excised large mammal hearts can be generated from ultrasonic images by utilizing the acoustic anisotropy of cardiac tissue. The goal of this paper is to demonstrate that detection of acoustic anisotropy and the creation of myocardial fiber maps using ultrasound is also feasible in rodents. Acoustic anisotropy of rat myocardium was confirmed using 2-mm diameter cores taken from the left-ventricular free wall using a 21 MHz probe (VisualSonics Vevo210) in B-mode. The relationship between fiber orientation and ultrasonic backscatter was obtained. These data were confirmed in segments of left ventricular free wall that were scanned and subsequently histologically sectioned serially from the epi- to endo-cardium. Subsequently, a series of long-axis images were taken from intact rat hearts to generate 3D rodent fiber maps. Preliminary data from mouse hearts using a 40 MHz probe produces similar results. We conclude that it is feasible to obtain...
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