Abstract
Biliary atresia (BA) is a progressive obliterative extrahepatic cholangiopathy of infants. Despite successful surgical drainage of bile, most children with BA experience progression of cirrhosis and liver failure. There is evidence that trans-differentiation of epithelial cells into collagen-producing mesenchymal cells during injury occurs secondary to Fibroblast Growth Factor (FGF) and Transforming Growth Factor-β (TGFβ) signaling activation. Therefore, we hypothesized that TGFβ-mediated epithelial-mesenchymal trans-differentiation (EMT) of hepatic progenitor cells contributes to periportal fibrosis associated with BA.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
