Abstract
Maintaining mineral metabolism requires several organs and hormones. Fibroblast growth factor 23 (FGF23) is a phosphatonin produced by bone cells that reduces renal production of calcitriol - 1,25(OH) 2D 3 - and induces phosphaturia. The consequences of a reduction in 1,25(OH) 2D 3 involve changes in calcium homeostasis. There are several factors that regulate FGF23: phosphorus, vitamin D, and parathyroid hormone (PTH). More recently, several studies have demonstrated that calcium also modulates FGF23 production. In a situation of calcium deficiency, the presence of 1,25(OH) 2D 3 is necessary to optimize intestinal absorption of calcium, and FGF23 is decreased to avoid a reduction in 1,25(OH) 2D 3 levels.
Highlights
The regulation of calcium (Ca) and phosphorus (P) is controlled mainly by the parathyroid hormone (PTH), vitamin D, and, to a lesser extent, calcitonin
They found that the stimulatory effect of Ca on Fibroblast growth factor 23 (FGF23) was present in the double knockout mice PTH-calciumsensing receptor (CaSR)
Systems regulating Ca and P homeostasis are closely related. This is illustrated by FGF23, which regulates Ca and P metabolism and is modulated by both elements
Summary
2. Jordi Bover, Department of Nephrology, Puigvert Foundation , Barcelona, Spain. Any comments on the article can be found at the end of the article. How to cite this article: Rodríguez-Ortiz ME and Rodríguez M.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
