Abstract
Chemotherapy is having various side effects and toxicities, to overcome these problems nanoparticles are formulated. Nanoparticles accumulate in the tumor cells due to enhanced permeation and retention effect. A series of poly (d, l-lactide-co-glycolide) PLGA and bovine serum albumin (Fraction V) BSA formulations were fabricated and used as nanocarriers for delivery of a promising anticancer drug paclitaxel (PTX). The eight formulations of nanoparticles of PTX-PLGA and PTX-BSA were prepared by using 23 factorial designs. PLGA (A,) poly vinyl alcohol (PVA) (B) and stirring speed (C) was used as independent variables where particle sizes (Y1), entrapment efficiency (Y2) and % drug release (Y3) were taken as dependant variables. PTX was efficiently encapsulated into the micelles by desolvation technique. The mean diameter of PTX-BSA and PTX-PLGA nanoparticles ranged from 104 to 1150 nm and 110 to 1023 nm respectively. The entrapment efficiency and in vitro drug release also depends on the solubility of drug and polymer in solvent. The use of design expert software is systematic tool for optimization technique, and also helps to reduce number of runs. Hence, in the present work, an attempt was made to formulate, evaluate and optimize particle size and entrapment efficiency of PTX-BSA and PTX-PLGA nanoparticles.
Highlights
Cancer is a leading cause of death, with more than 10 million people being diagnosed with the disease annually
The mean particle size of nanoparticles formulation was in the range of nm
In case of formulations prepared by Bovine Serum Albumin (BSA), the size of particles can be affected by concentration of polymer, pH, ratio of acetone/BSA and surfactant Tween 80
Summary
Cancer is a leading cause of death, with more than 10 million people being diagnosed with the disease annually. The difficulty of drug to target in tumor tissue is the main problem of cancer therapy. In cancer cells division is uncontrolled and which have the ability to attack other biological tissues. Chemotherapy is the chief curative approach for the treatment of cancers. The lack of cite specificity to cancer cells by anticancer drugs, the selective amplified uptake in cancerous tissue would be of massive interest in cancer chemotherapy [3]. The focus is on targeted cancer therapy. The novel approaches to cancer treatment complement the conventional chemotherapy and radiotherapy and suppress the damage to normal tissues and avoid drug resistance [1]
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