Abstract
Fexofenadine HCl is a second-generation antihistamine which is commonly used for allergic disorders. But it has low bioavailability. Intranasal corticosteroids (INCs) and Immunotherapy and Allergen Specific Immunotherapy (ASIT) are now commonly being suggested for the treatment of allergic disorders. Despite the fact that current treatment alternatives have been in use for decades, patient quality of life has remained static. The treatment options are not much explored for their respective adverse effects. Therefore, they are in desperate need of research. Fexofenadine HCl is available in the form of a suspension, tablet, or capsule. In our current study, we have explored whether microspheres can be the perfect dosage form of Fexofenadine HCl to treat allergic disorders considering the pharmacokinetics of the drug, available dosage forms options and the probable side effects of the current therapies.
Highlights
Fexofenadine HCl is a second-generation antihistamine which is commonly used for allergic disorders
We have explored whether microspheres can be the perfect dosage form of Fexofenadine HCl to treat allergic disorders considering the pharmacokinetics of the drug, available dosage forms options and the probable side effects of the current therapies
We suggest that microspheres can be the perfect dosage form of Fexofenadine HCl to treat allergic disorders
Summary
Effective treatment options for allergic disorders may help the patients achieve a higher quality of life. Researchers are always attempting to identify methods to lessen the side effects of drugs by altering the molecule, site specific targeted medication release, and dosage forms and dosage forms with cost-effectiveness. Due to the reduced effectiveness of Fexofenadine HCl, i.e. its lesser bioavailability, intranasal corticosteroids (INCS), subcutaneous, and sublingual immunotherapy have been recommended as current therapeutic options. If Fexofenadine HCl efficacy can be increased by boosting bioavailability, it might be the ‘state of art’ alternative for patients in every way: convenience, cost effectiveness, and a large margin of safety
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