Abstract
Objectives To study the effect of fetal stem cell (FSC) therapy on Grade I and II respiratory failure in patients with amyotrophic lateral sclerosis (ALS) and muscular dystrophy (MD). Methods A comparative study was conducted on 41 patients with Grade I or II respiratory failure (RF) resulting from ALS or MD. The patients were divided into 4 groups according to the underlying disease and the degree of RF. Patients underwent combined treatment, including the experimental application of FSC therapy, and were examined before FSC treatment, and 6 months and 12 months after treatment. Results FSC treatment improved both subjective and objective breathing parameters as early as 6 months post-treatment. A significant increase in the forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) was reported by all patients with Grade I RF linked to ALS and MD compared to baseline. Patient respiratory improvement was maintained over the next 6 months. Grade II RF patients with MD reported a significant improvement in FVC 12 months after treatment. Conclusions Evidence for respiratory improvement was observed as early as 6 months in all patients after combined treatment including FSC therapy, and this was maintained for a further 6 months after therapy. In MD patients with Grade II RF, treatment resulted in a significant FVC and FEV1 increase within 6 months and downgrading to Grade I RF within a year after FSC treatment.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.