Abstract
Polycystic ovarian syndrome (PCOS) is characterized by elevated androgens, and it is a risk factor for GDM. Androgens (particularly DHEAS) are crucial for the development of the male reproductive tract during fetal life, and fetal DHEAS enters the placenta where it is metabolized and functions as an estrogen substrate. Given this unique sex-specific relationship, we hypothesized that metabolic comorbidities in pregnancy might differ by fetal sex in women with PCOS. Our objective was to employ a large population-based database to identify if fetal sex was associated with GDM in gravidae with PCOS after controlling for confounders.
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