Abstract
Maternal adaptations in pregnancy induce complex physiological changes of the immune system which protect mother’s health and ensure the accommodation of the growing embryo. The innate immunity is amplified and the adaptive immunity is partially suppressed, preserving the ability to produce antibodies. Vaccination during pregnancy constitutes a fundamental preventive measure in the antenatal care, as it achieves both the immunization of the mother and the baby. Besides passive immunization through the placenta, also active transfer of IgG via placenta occurs throughout pregnancy. Live attenuated vaccines (LAV) are contraindicated in pregnant women, while the others should be recommended if benefits overshadow risks.
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