Abstract
The specific activity of phosphatidic acid phosphohydrolase (PAPase) has been determined in the fetal rabbit lung, from day 20 of gestation to 2 days <i>post partum. </i>The activity increases four fold from day 23 to adult levels on day 30. No change was found in the liver phosphatidic acid phosphohydrolase or lung CDP-choline:diglyceride transferase activities. The increase in activity of the enzyme in fetal rabbit lung precedes by 24 h, the increase in phosphatidylcholine concentration. The increase in phosphatidic acid phosphohydrolase activity may function in the regulation of phosphatidylcholine biosynthesis in the developing lung by increasing the availability of substrates for phosphatidylcholine biosynthesis.
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