Abstract
Objective: To corelate the Hb F levels with clinical parameters of patients with sickle cell disease and sickle beta thalassemia. Study Design: Cross Sectional study. Setting: Chughtai Institute of Pathology. Period: June 2020 to December 2021. Material & Methods: A total of 150 diagnosed cases of sickle cell disease and sickle beta thalassemia were included in the study. Hemoglobin electrophoresis was performed and Hb F levels were noted. Detailed history of patients regarding their complications was taken. Data analysis was done using SPSS 23.0. Correlation of Hb F with Hb levels, splenomegaly, other symptoms and number of transfusions required was observed using Pearson test taking P value <0.05 as significant. Results: A significant correlation was observed between Hb F levels and Hb levels, splenomegaly, joint pains, jaundice, acute chest syndrome and number of transfusions required by the patient. Conclusion: We observed that high levels of Hb F in patients of sickle cell disease have fewer complications and have less need for repeated blood transfusions. Therefore, we recommend that Hb F levels must be noted at the time of diagnosis so that early treatment with hydroxyurea can be started to increase Hb F levels.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
