Fetal heart rate short term variation during labor in relation to scalp blood lactate concentration.

Abstract

Fetal heart rate short term variation (STV) decreases with severe chronic hypoxia in the antenatal period. However, only limited research has been done on STV during labor. We have tested a novel algorithm for a valid baseline estimation and calculated STV. To explore the value of STV during labor, we compared STV with fetal scalp blood (FBS) lactate concentration, an early marker in the hypoxic process. Software was developed which estimates baseline frequency using a novel algorithm and thereby calculates STV according to Dawes and Redman in up to four 30-minute blocks prior to each FBS. Cardiotocography traces from 1070 women in labor who had had FBS performed on 2134 occasions were analyzed. In acidemic cases (lactate >4.8mmol/L; Lactate Pro™), median STV 30minutes prior to FBS was 7.10milliseconds compared with 6.09milliseconds in the preacidemic (4.2-4.8mmol/L) and 5.23milliseconds in the normal (<4.2mmol/L) groups (P<.05). There was a positive correlation between lactate and STV (rho=0.16-0.24; P<.05). Median lactate concentration in cases with STV <3.0milliseconds (n=160) was 2.3mmol/L. When 2 FBS were performed within 60minutes the change rate of lactate correlated to STV (rho=0.33; P<.001). Cases with increasing lactate concentration had a median STV of 5.29milliseconds vs 4.41milliseconds in those with decreasing lactate (P<.001). In the early stages of intrapartum hypoxia, STV increases, contrary to findings regarding chronic hypoxia in the antenatal period. The increase in the adrenergic surge is a likely explanation.