Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus that, having crossed species, has caused human disease from 2019 - COrona Virus Disease 2019 (COVID-19). Pregnant women are potentially at high risk of contracting SARS-CoV-2 infection when compared to non-pregnant matched controls. Pregnancy is also complicated with a higher risk of developing severe SARS-CoV-2, including respiratory diseases, admission to the intensive care unit and mortality, even after adjusting for confounding risk factors. Moreover, data on the effect on fetal outcome including preterm delivery and perinatal morbidity are still conflicting, the risk of vertical transmission (i.e., transmission of SARS-CoV-2 from the mother to the fetus or the newborn) is considered low but there is evidence that a significant proportion of placentas where SARS-CoV-2 occurred during pregnancy show histopathological findings suggesting placental hypoperfusion and inflammation. In this review we will present the available data on the effects of SARS-CoV-2 infection on fetal growth and maternal hemodynamics
Highlights
SARS-CoV-2 virus induce changes in the placenta, mainly characterized Вирус SARS-CoV-2 вызывает изменения плаценты, которые в осby hypoperfusion and inflammation новном характеризуются гипоперфузией и воспалением. These placenta changes do not seem associated with changes in fetal Эти изменения плаценты, по-видимому, не ассоциированы с измеgrowth and hemodynamics нениями роста плода и гемодинамики
The potential association between SARS-CoV-2 and impaired placental function is crucial because it might lead to changes in fetal growth, hemodynamic decompensation and increased risk of perinatal mortality and morbidity
Макина Паула, MD, Университет Рома Тор Вергата, отделение медицины матери и плода, Госпиталь Кристо Ре
Summary
SARS-CoV-2 virus induce changes in the placenta, mainly characterized Вирус SARS-CoV-2 вызывает изменения плаценты, которые в осby hypoperfusion and inflammation новном характеризуются гипоперфузией и воспалением. These placenta changes do not seem associated with changes in fetal Эти изменения плаценты, по-видимому, не ассоциированы с измеgrowth and hemodynamics нениями роста плода и гемодинамики
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