Abstract
Abstract: For the biocompatibility test of implantable devices or for the sensitivity evaluation of biomedical sensors,it is required to understand the mechanism of the protein adsorption and the interaction between the adsorbed pro-teins and cells. In this study, the adsorption of proteins in a cell culture medium with fetal bovine serum onto anindium tin-oxide electrode was characterized by using linear sweep voltammetry and impedance spectroscopy. Weimmersed the fabricated ITO electrodes in the culture medium for 30, 60, or 90 min, and then measured the elec-trochemical properties of electrodes with 10 mM Fe(CN) 63−/4− and 0.1 M KCl electrolyte. With an increase of con-tacting time, the anodic peak current was decreased and the charge transfer resistance was increased. However, bothparameters were recovered to the values before contact with the medium after the treatment of Trypsin/Ethyl-enediaminetetraacetic acid hydrolyzing proteins.Key words: Adsorption, Electrode interface, Impedance spectroscopy, Linear sweep voltammetry, Protein
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