Abstract
Fetal anaemia in pregnancy, although less prevalent since the introduction of anti-D immunoglobulin, remains a clinical issue. In this article the authors describe two clinical cases of challenging fetal anaemia; the first following a parvovirus B19 infection during pregnancy and the second after Rh isoimmunization (due to Rh positive maternal transfusions in childhood), sooner and more severe in a second pregnancy. A brief review of the topic was also conducted.
Highlights
Isoimmunization occurs in subsequent pregnancies, causing haemolytic disease of the fetus or newborn (NB), characterized by hemolysis, bilirubin release, and anaemia
The severity of the disease will depend on the degree of immune response, the gestational age at the diagnosis, and the fetal capacity to replace the destroyed erythrocytes, maintaining a sufficient hematocrit for their growth and development [1-3]
Fetal anaemia in pregnancy remains a diagnosis of suspicion
Summary
Summary Fetal anaemia in pregnancy, less prevalent since the introduction of anti-D immunoglobulin, remains a clinical issue.
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